Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 70 0.0 0.723 0.079 0.159
biological_process el 70 0.011 0.966 0.618 0.246
biological_process ka 70 0.0 0.698 0.075 0.158
biological_process rf 70 0.0 0.723 0.079 0.159
cellular_component ct 71 0.0 0.874 0.125 0.196
cellular_component el 71 0.007 0.994 0.578 0.27
cellular_component ka 71 0.0 0.886 0.128 0.198
cellular_component rf 71 0.0 0.87 0.125 0.195
disease ct 25 0.001 0.954 0.159 0.279
disease el 25 0.005 0.931 0.221 0.276
disease ka 25 0.0 0.948 0.166 0.297
disease rf 25 0.001 0.957 0.159 0.279
genetic_interaction_weighted ct 73 0.0 0.996 0.304 0.297
genetic_interaction_weighted el 73 0.007 0.996 0.53 0.297
genetic_interaction_weighted ka 73 0.0 0.994 0.302 0.289
genetic_interaction_weighted node2vec 73 0.0 0.981 0.458 0.336
genetic_interaction_weighted rf 73 0.0 0.996 0.304 0.297
molecular_function ct 71 0.0 0.994 0.148 0.279
molecular_function el 71 0.002 0.959 0.527 0.267
molecular_function ka 71 0.0 0.975 0.151 0.277
molecular_function rf 71 0.0 0.994 0.148 0.279
pathway ct 30 0.001 0.996 0.069 0.18
pathway el 30 0.001 0.185 0.027 0.047
pathway ka 30 0.001 1.0 0.307 0.454
pathway node2vec 30 0.001 0.677 0.107 0.183
pathway rf 30 0.001 0.157 0.03 0.044
phenotype ct 26 0.0 0.864 0.203 0.272
phenotype el 26 0.03 0.853 0.497 0.195
phenotype ka 26 0.0 0.968 0.22 0.299
phenotype rf 26 0.0 0.867 0.203 0.272
protein_interaction ct 73 0.0 0.777 0.037 0.129
protein_interaction el 73 0.0 0.681 0.034 0.115
protein_interaction ka 73 0.001 1.0 0.347 0.472
protein_interaction node2vec 73 0.002 0.774 0.057 0.146
protein_interaction rf 73 0.0 0.647 0.033 0.109

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 73 0.0 0.632 0.038 0.108
integration_mean_by_presence el 73 0.0 0.862 0.037 0.119
integration_mean_by_presence ka 73 0.0 0.713 0.048 0.139
integration_mean_by_presence node2vec 73 0.0 0.918 0.12 0.187
integration_mean_by_presence rf 73 0.0 0.315 0.025 0.061
mean ct 73 0.0 0.72 0.039 0.118
mean el 73 0.0 0.348 0.032 0.082
mean ka 73 0.0 0.48 0.034 0.092
mean node2vec 73 0.0 0.724 0.075 0.129
mean rf 73 0.0 0.32 0.032 0.075

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels